Rituxan

Rituxan—IDEC-C2B8 Project Team (rituximab)

Pictured is a coffee cup with a story. Last year, my brother Chris was diagnosed with non-Hodgkin’s lymphoma. He believes that he caught this cancer from his exposure to the herbicide Roundup. After this was diagnosed, his oncologist prescribed Rituxan the first monoclonal antibody drug developed for cancer. So last year, in addition to caring for our already ailing father, he had to contend with his own illness. He was prescribed roughly half-a-dozen monthly infusions of the drug. Even after his first dose, there was a marked improvement. By the end of his regimen, he was pronounced cured. But this story began long before.

Rituxan was developed by IDEC Pharmaceuticals, a San Diego pharmaceutical company that focused on developing and commercializing targeted immuno-therapies for cancer and autoimmune diseases. In the early nineties, Kathy, Frank’s wife, was a director there. More particularly she was the project manager for the development of Rituxan. It made a big news splash at rollout and not in a good way as the $2,000 a dose cancer drug, which back then was deemed exorbitant. Times change. For Chris, Rituxan’s cure for cancer would have cost twelve-grand, but Medicare paid for everything. Such a deal! Anyway, in 2003, IDEC merged with Biogen, where Frank was working, to form Biogen-IDEC, which later became just Biogen. Kathy and Frank both retired shortly after the merger, sold their stock options and have been living the good life ever since. Later this week, Anne and I are planning on taking a break from “flinging” to stay as guests at their vacation rental, on the coast of Mendicino. 

Lost in the Fog

The Fog Rolls In

The weather in Monterey changes more with the time of day than it does from day-to-day. This morning it was foggy. The fog rolled in and then rolled out, much like the waves in the ocean below it. Today, featured a full day of senior care. In the morning, Chris and I gave dad a bath. Later, I did a grocery shop. I thought that groceries were expensive at home, but compared to prices out here, we are getting off easy at home. In the afternoon, the visiting nurses arrived. One nurse cared for dad, rebandaging his foot, while the other spoke with us. I got the feeling that she was evaluating us as much as dad, but it looks like we will be getting more help, eventually. Tomorrow, we have a field trip. Oh, boy!

Anti-Vax Pro-Plague

Measles Plushy

I am old enough to remember if a child in the neighborhood contracted measles, mothers would marshal all of the other children to the stricken child’s bedside and have a measles party. In this era before vaccinations, the idea of such an exercise was if you were going to have one sick kid, you might as well get it over with for all of the rest them. I can remember contracting one of these diseases and my visiting out-of-town cousins were ushered into my sick room, to spend some “quality” time with me. Back then these so-called childhood diseases were inevitable. Nowadays, we have a vaccine and measles, mumps, and rubella (MMR) have been packaged together into one convenient shot.

This year, a measles epidemic is running rampant across the country. Originating in West Texas, it has spread across the country, killing children as it goes. This plague popped up on my radar early, because we were planning a western road trip that was planned to pass through the hot zone. This concerned me. I am too old for the vaccine, and I am also too old to remember exactly which diseases I had had. Due to other circumstances this road trip was kicked down the road to another year, but the measles epidemic has continued unabated. This week, after asking my doctor, I got the measles titer. Actually, I got the MMR titer. The good news is that I am immune to all three. I guess those measles parties worked! 🙂

Yesterday, when I went in for the blood draw, I mentioned to the medical professional my fuzzy memory. She said that it wasn’t just a matter of whether or not I had had the diseases, but also whether after all of these years I had retained my immunity. Today, I got a text from my doctor reinforcing this. The messaging app used also contains a wealth of auxiliary information. On an MRI I once got, the results also came back positive in the form that I was pronounced “grossly normal,” as opposed to normally gross. My measles titer’s result was 300, where anything above 16.4 is considered good. My titer result is good, but not great.  Further “research” clouded my initial joy about my high score. A value of 2000 would put me in the “League of Legends.” Leaving me with a question for my doctor when I see him next month.

I Got Jesus Freckles!

Measles Plushy

On my car that is. Thursday, in preparation for this road trip, I got the car washed. I went full boat ($55). It is a lot, but the car looked great, but only for one day. It was not supposed to rain, but it did. Worst this rain precipitated dust from Texas that had been blown aloft. In the morning, the car was covered in brown dots, from muddy dried raindrops. News of this phenomenon made the local weather. The source for this brown rain was identified as Lubbock, TX. In addition to the source for this mess, Lubbock is also ground zero for the current measles epidemic that is spreading across Texas and further around the country. Is there any chance that the brown residue has been infected? The measles virus is supposed to be super persistent. I hear that they are running out of vaccine in Texas. I take this as good news, because people are now getting vaccinated.

Measles are one worry, but another one just appeared out of the either. Anne’s showed a warning that an unknown AirTag was traveling with us. It appeared first in Ohio and then again in Pennsylvania. We did not know what to make of this new unknown. AirTags were designed to track things, like your keys, but nefarious people use these things to track other people. Anne’s phone is new enough to have a safety feature that alerted us to this issue. I worried about it, but in the morning when I went looking for the device, I could not find it. In the end I decided that it was all a false alarm.

Anyway, we are in Philly now. Last night we overnighted near Pittsburgh.

The Eyes Have It

Eye-Aye

I went to the eye doctor today. Good news! It has been almost four years since my cataract surgery and my corrected vision is still good. Before the surgery I was extremely nearsighted (20/200 and 20/400). Today, my corrected vision is 20/20 and 20/25 respectively. There has been no drifting in my vision. I still wear glasses, but it is more for eye protection and habit than for vision.

Additionally, when I had the cataract surgery, I also got stents in both eyes. These stents relieve the too high pressure in both eyes caused by glaucoma and if untreated would lead to blindness. I recounted a story to my present doctor/surgeon about his predecessor Kayes. I first met him thirty years ago when he first diagnosed my glaucoma. He prescribed eyedrops, beta-blockers, as treatment. The way he put it the alternatives were either the eyedrops or having holes drilled in my eyeballs. I recoiled from the idea of this surgery. This recoil got doubled downed when I spied a collage of old eye surgery implements that was then office decoration. Fastforward the quarter century that I had spent using these eyedrops, when I had my surgery and got holes poked in my eyes.

But wait there is more. Macular degeneration runs in my family. This is a disease that affects the retina. My dad has it, as did his mother and sister. I always ask about this condition when I see the doctor and this time the news was good, no sign of this condition. I will be vigilant and always ask in the future.

I-N-F-L-U-E-N-Z-A Blues


This 1919 sheet music cover for I-N-F-L-U-E-N-Z-A Blues, by white songwriters Happy Klark and Arthur C. Brown, features racist minstrel stereotypes widely used in American entertainment in the 19th and early 20th centuries. “Minstrel shows” of white performers in blackface dominated early vaudeville and radio programs, mocking Black culture in offensive caricatures. Like the one featured on this cover, tropical settings evoked white supremacist notions of an uncivilized culture, equating the music with a “primitive” sensibility. In addition to spreading harmful stereotypes, minstrelsy set demeaning expectations for Black performers, as audiences expected Black artists to meet the vulgarized standards of minstrel performance. The music recording and publishing industries adhered to these racist trends in popular culture, and this imagery is often associated with early “race records” and Ragtime “Blues” compositions.

Please consider this post an example of my DEI antidote to the torrent of racist rhetoric that is spewing daily now from our nation’s capital. Afterall, it is February, Black History month. At least I think that it still is. They have not changed that yet, or have they? It is still early. I am sure that they will get to it.

This song commemorated the 1919 epidemic, the so-called Spanish flu. The one before the 2020 pandemic. Its lyrics rail against this plague. Explaining that this disease affects both the rich and poor, “It killed the rich, killed the poor.” Unlike Covid, which was more deadly to the old, that flu tended to kill the young and healthy. The tune views this malady as God’s judgement upon our land, but as the cover sheet claims, it still makes for wonderful dance music. We are both vaccinated and have so far escaped getting sick this winter. Knock on wood.